Gene

tfr1a

ID
ZDB-GENE-041220-1
Name
transferrin receptor 1a
Symbol
tfr1a Nomenclature History
Previous Names
  • chianti
  • cia
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have transferrin receptor activity. Involved in cellular iron ion homeostasis; hemoglobin biosynthetic process; and hemopoiesis. Predicted to localize to external side of plasma membrane. Human ortholog(s) of this gene implicated in breast carcinoma; multiple myeloma; ovarian cancer; and primary immunodeficiency disease. Is expressed in blood; blood island; intermediate cell mass of mesoderm; presumptive blood; and ventral mesoderm. Orthologous to human TFRC (transferrin receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tfr1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 46 Alliance Immunodeficiency 46 616740
Associated With tfr1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003137 PA domain
Domain IPR007365 Transferrin receptor-like, dimerisation domain
Domain IPR007484 Peptidase M28
Domain IPR037324 Transferrin receptor protein 1/2, PA domain
Family IPR029513 Transferrin receptor protein 1
Family IPR039373 Glutamate carboxypeptidase 2-like
Homologous_superfamily IPR036757 Transferrin receptor-like, dimerisation domain superfamily
Domain Details Per Protein
Protein Length Glutamate carboxypeptidase 2-like PA domain Peptidase M28 Transferrin receptor-like, dimerisation domain Transferrin receptor-like, dimerisation domain superfamily Transferrin receptor protein 1 Transferrin receptor protein 1/2, PA domain
UniProtKB:B3DHD1 770
UniProtKB:Q5MPX4 770
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations