ZFIN is now using GRCz12tu for Genomic Data
Gene
ift80
- ID
- ZDB-GENE-041212-50
- Name
- intraflagellar transport 80 homolog (Chlamydomonas)
- Symbol
- ift80 Nomenclature History
- Previous Names
-
- wu:fj11a06
- zgc:101763
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within several processes, including cilium assembly; convergent extension; and retina morphogenesis in camera-type eye. Predicted to be located in motile cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and cilium. Is expressed in several structures, including eye; notochord; pectoral fin; pectoral fin bud; and pronephric duct. Used to study asphyxiating thoracic dystrophy; asphyxiating thoracic dystrophy 2; and ciliopathy. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 2. Orthologous to human IFT80 (intraflagellar transport 80).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101763 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| asphyxiating thoracic dystrophy 2 | Alliance | Short-rib thoracic dysplasia 2 with or without polydactyly | 611263 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR056157 | IFT80/172/WDR35, TPR domain |
| Domain | IPR056456 | IFT80, second beta-propeller domain |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | IFT80/172/WDR35, TPR domain | IFT80, second beta-propeller domain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BKN3 | InterPro | 779 | |||||
| UniProtKB:Q5PRA9 | InterPro | 777 | |||||
| UniProtKB:A0AB32T3M4 | InterPro | 777 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers