ZFIN is now using GRCz12tu for Genomic Data
Gene
erg
- ID
- ZDB-GENE-041212-40
- Name
- ETS transcription factor ERG
- Symbol
- erg Nomenclature History
- Previous Names
-
- erg1 (1)
- zgc:103429
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within angiogenesis and hemangioblast cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in hereditary lymphedema and myeloid leukemia. Orthologous to human ERG (ETS transcription factor ERG).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103429 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Liu et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lymphatic malformation 14 | 620602 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ets domain | ETS family | Pointed domain | Sterile alpha motif/pointed domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5PR65 | InterPro | 427 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-134J13 | ||
| Encodes | cDNA | MGC:103429 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192934 | ZFIN Curated Data | |
| Is Hybridized by | EST | fa11a02 |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001008616 (1) | 2811 nt | ||
| Genomic | GenBank:CU499177 (1) | 59339 nt | ||
| Polypeptide | UniProtKB:Q5PR65 (1) | 427 aa |
- Neal, A., Nornes, S., Louphrasitthiphol, P., Sacilotto, N., Preston, M.D., Fleisinger, L., Payne, S., De Val, S. (2021) ETS factors are required but not sufficient for specific patterns of enhancer activity in different endothelial subtypes. Developmental Biology. 473:1-14
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Keightley, M.C., Carradice, D.P., Layton, J.E., Pase, L., Bertrand, J.Y., Wittig, J.G., Dakic, A., Badrock, A.P., Cole, N.J., Traver, D., Nutt, S.L., McCoey, J., Buckle, A.M., Heath, J.K., Lieschke, G.J. (2017) The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger. Nature communications. 8:14911
- Macaulay, I.C., Svensson, V., Labalette, C., Ferreira, L., Hamey, F., Voet, T., Teichmann, S.A., Cvejic, A. (2016) Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Cell Reports. 14(4):966-77
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Veldman, M.B., Zhao, C., Gomez, G.A., Lindgren, A.G., Huang, H., Yang, H., Yao, S., Martin, B.L., Kimelman, D., and Lin, S. (2013) Transdifferentiation of fast skeletal muscle into functional endothelium in vivo by transcription factor etv2. PLoS Biology. 11(6):e1001590
- Wythe, J.D., Dang, L.T., Devine, W.P., Boudreau, E., Artap, S.T., He, D., Schachterle, W., Stainier, D.Y., Oettgen, P., Black, B.L., Bruneau, B.G., and Fish, J.E. (2013) ETS Factors Regulate Vegf-Dependent Arterial Specification. Developmental Cell. 26(1):45-58
- Lindeman, L.C., Reiner, A.H., Mathavan, S., Aleström, P., and Collas, P. (2010) Tiling histone h3 lysine 4 and 27 methylation in zebrafish using high-density microarrays. PLoS One. 5(12):e15651
- Ren, X., Gomez, G.A., Zhang, B., and Lin, S. (2010) Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells. Blood. 115(26):5338-5346
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