Gene

iqsec3a

ID

ZDB-GENE-041210-343

Name

IQ motif and Sec7 domain ArfGEF 3a

Symbol

iqsec3a Nomenclature History

Previous Names

si:ch211-15l13.1 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have ARF guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Is expressed in central nervous system and neurons. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7141416 (3 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With iqsec3a Human Ortholog

No data available

Associated With iqsec3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000904	Sec7 domain
Domain	IPR033742	IQ motif and SEC7 domain-containing protein, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR023394	Sec7, C-terminal domain superfamily
Homologous_superfamily	IPR035999	Sec7 domain superfamily

Domain Details Per Protein

Protein	Length	IQ motif and SEC7 domain-containing protein, PH domain	IQ motif, EF-hand binding site	PH-like domain superfamily	Sec7, C-terminal domain superfamily	Sec7 domain	Sec7 domain superfamily
UniProtKB:A0A8M9Q145 InterPro	1134
UniProtKB:A0A8M9Q6D3 InterPro	933
UniProtKB:A0A8M9PXS3 InterPro	1053
UniProtKB:A0A8M9QBX1 InterPro	1117
UniProtKB:A0A8M3ART2 InterPro	1285
UniProtKB:A0A8M9Q4E3 InterPro	701
UniProtKB:A0A8M3AYW6 InterPro	865
UniProtKB:A0A8M3B1U5 InterPro	1143

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	iqsec3a-201 (1) Ensembl	Havana	5161 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ottdart00000061758 (1) Ensembl	Havana	1133 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations