Gene

smarcal1

ID
ZDB-GENE-041210-303
Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Symbol
smarcal1 Nomenclature History
Previous Names
  • im:7145331 (1)
  • si:ch211-239d11.1
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable ATP-dependent DNA/DNA annealing activity. Acts upstream of or within several processes, including angiogenesis; cartilage development; and embryonic body morphogenesis. Predicted to be located in nucleus. Predicted to be active in nuclear replication fork. Is expressed in central nervous system; immature eye; and intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in Schimke immuno-osseous dysplasia. Orthologous to human SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Huang et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smarcal1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Schimke immuno-osseous dysplasia Alliance Schimke immunoosseous dysplasia 242900
Associated With smarcal1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000330 SNF2, N-terminal
Domain IPR001650 Helicase, C-terminal
Domain IPR010003 HARP domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Family IPR030101 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length HARP domain Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase SNF2-like, N-terminal domain superfamily SNF2, N-terminal SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
UniProtKB:A0A0R4IYD9 398
UniProtKB:B2ZFP3 807
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations