Gene
pde3a
- ID
- ZDB-GENE-041210-23
- Name
- phosphodiesterase 3A, cGMP-inhibited
- Symbol
- pde3a Nomenclature History
- Previous Names
-
- si:dkey-48h7.2
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in negative regulation of cAMP/PKA signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in oocyte and oocyte stage V. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Pang et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypertension and brachydactyly syndrome | Alliance | Hypertension and brachydactyly syndrome | 112410 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003607 | HD/PDEase domain |
| Homologous_superfamily | IPR036971 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | HD/PDEase domain |
|---|---|---|---|---|---|---|
| UniProtKB:F6P4K3 | InterPro | 1117 | ||||
| UniProtKB:A0A8M3ARD3 | InterPro | 1123 | ||||
| UniProtKB:A0A8M3B8Q1 | InterPro | 1124 | ||||
| UniProtKB:A0A8M3AYI3 | InterPro | 1106 | ||||
| UniProtKB:A0AB32TLS2 | InterPro | 870 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(HSE:pde3a,HSE:GFP) |
|
| 1 | Xu et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-48H7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068220715 (1) | 8872 nt | ||
| Genomic | GenBank:BX323818 (1) | 196712 nt | ||
| Polypeptide | UniProtKB:A0A8M3B8Q1 (1) | 1124 aa |
- Pang, Y., Thomas, P. (2018) Role of natriuretic peptide receptor 2-mediated signaling in meiotic arrest of zebrafish oocytes and its estrogen regulation through G protein-coupled estrogen receptor (Gper). General and comparative endocrinology. 265:180-187
- Xu, J., Jia, Y.F., Tapadar, S., Weaver, J.D., Raji, I.O., Pithadia, D.J., Javeed, N., García, A.J., Choi, D.S., Matveyenko, A.V., Oyelere, A.K., Shin, C.H. (2018) Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells. Scientific Reports. 8:15587
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Potok, M.E., Nix, D.A., Parnell, T.J., and Cairns, B.R. (2013) Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern. Cell. 153(4):759-772
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