Gene
tfec
- ID
- ZDB-GENE-041210-21
- Name
- transcription factor EC
- Symbol
- tfec Nomenclature History
- Previous Names
-
- si:ch211-238e6.5
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including closure of optic fissure; hematopoietic stem cell homeostasis; and hemopoiesis. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including eye; immature eye; intermediate cell mass of mesoderm; neural crest; and post-vent region. Orthologous to human TFEC (transcription factor EC).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | MiT/TFE transcription factors, C-terminal | MiT/TFE transcription factors, N-terminal | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PUG4 | InterPro | 385 | ||||
| UniProtKB:A0A8M6Z5C1 | InterPro | 325 | ||||
| UniProtKB:A0A8M2BBP2 | InterPro | 395 | ||||
| UniProtKB:Q1JQ62 | InterPro | 396 | ||||
| UniProtKB:A0AB32TNY3 | InterPro | 434 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-238E6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136250 | ZFIN Curated Data |
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- Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Diez Del Corral, R., Neuhauss, S.C.F., Martínez-Morales, J.R. (2023) Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. eLIFE. 12:
- Tang, C.Y., Zhang, X., Xu, X., Sun, S., Peng, C., Song, M.H., Yan, C., Sun, H., Liu, M., Xie, L., Luo, S.J., Li, J.T. (2023) Genetic mapping and molecular mechanism behind color variation in the Asian vine snake. Genome biology. 24:4646
- Cechmanek, P.B., Hehr, C.L., McFarlane, S. (2021) Retinal Pigment Epithelium and Neural Retinal Progenitors Interact Via Semaphorin 6D to Facilitate Optic Cup Morphogenesis. eNeuro. 8(3):
- Howard, A.G., Baker, P.A., Ibarra-García-Padilla, R., Moore, J.A., Rivas, L.J., Tallman, J.J., Singleton, E.W., Westheimer, J.L., Corteguera, J.A., Uribe, R.A. (2021) An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution. eLIFE. 10:
- Jang, H.S., Chen, Y., Ge, J., Wilkening, A.N., Hou, Y., Lee, H.J., Choi, Y.R., Lowdon, R.F., Xing, X., Li, D., Kaufman, C.K., Johnson, S.L., Wang, T. (2021) Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish. Genome biology. 22:282
- Petratou, K., Spencer, S.A., Kelsh, R.N., Lister, J.A. (2021) The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor. PLoS One. 16:e0244794
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Sommer, F., Torraca, V., Xie, Y., In 't Veld, A.E., Willemse, J., Meijer, A.H. (2021) Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal. Cell Reports. 35:109000
- Sinagoga, K.L., Larimer-Picciani, A.M., George, S.M., Spencer, S.A., Lister, J.A., Gross, J.M. (2020) Mitf-family transcription factor function is required within cranial neural crest cells to promote choroid fissure closure. Development (Cambridge, England). 147(21):
- Rougeot, J., Torraca, V., Zakrzewska, A., Kanwal, Z., Jansen, H.J., Sommer, F., Spaink, H.P., Meijer, A.H. (2019) RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in immunology. 10:832
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