Gene

lepb

ID
ZDB-GENE-041210-183
Name
leptin b
Symbol
lepb Nomenclature History
Previous Names
  • si:dkey-21o22.1
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable hormone activity. Acts upstream of or within several processes, including glucose homeostasis; regulation of glucose metabolic process; and response to starvation. Predicted to be located in extracellular region. Is expressed in digestive system; gill; heart; hypophysis; and pleuroperitoneal region. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (leptin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from He et al., 2021
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lepb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital leptin deficiency Alliance Obesity, morbid, due to leptin deficiency 614962
Associated With lepb Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000065 Leptin
Homologous_superfamily IPR009079 Four-helical cytokine-like, core
Domain Details Per Protein
Protein Length Four-helical cytokine-like, core Leptin
UniProtKB:C4WYH6 168
UniProtKB:Q5TYZ1 119
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations