Gene
wnt7ba
- ID
- ZDB-GENE-041210-178
- Name
- wingless-type MMTV integration site family, member 7Ba
- Symbol
- wnt7ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway; neuron differentiation; and positive regulation of JNK cascade. Predicted to be active in extracellular space. Is expressed in several structures, including brain; midbrain neural rod; presumptive diencephalon; presumptive telencephalon; and swim bladder. Orthologous to human WNT7B (Wnt family member 7B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015357Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa26281 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31394 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wnt | Wnt-7 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:F1Q5B7 | InterPro | 353 | ||||
| UniProtKB:A0AB32TPM4 | InterPro | 368 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
wnt7ba-201
(1)
|
Ensembl | 1,062 nt | ||
| mRNA |
wnt7ba-202
(1)
|
Ensembl | 1,016 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-239E6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068220765 (1) | 3728 nt | ||
| Genomic | GenBank:BX649425 (1) | 133503 nt | ||
| Polypeptide | UniProtKB:A0AB32TPM4 (1) | 368 aa |
- Chen, F., Deng, Z., Wang, X., Liu, Y., Zhao, K., Zhang, Y., He, S., Ran, R., Dong, Y., Guo, S., Zhou, Y., Zhou, B., Pang, P., Ge, W., Liu, C., Shan, H., He, H. (2025) DDX24 spatiotemporally orchestrates VEGF and Wnt signaling during developmental angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 122:e2417445122e2417445122
- Sebo, D.J., Ali, I., Fetsko, A.R., Trimbach, A.A., Taylor, M.R. (2025) Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation. Scientific Reports. 15:34963496
- Bouasker, S., Patel, N., Greenlees, R., Wellesley, D., Fares Taie, L., Almontashiri, N.A., Baptista, J., Alghamdi, M.A., Boissel, S., Martinovic, J., Prokudin, I., Holden, S., Mudhar, H.S., Riley, L.G., Nassif, C., Attie-Bitach, T., Miguet, M., Delous, M., Ernest, S., Plaisancié, J., Calvas, P., Rozet, J.M., Khan, A.O., Hamdan, F.F., Jamieson, R.V., Alkuraya, F.S., Michaud, J.L., Chassaing, N. (2022) Bi-allelic variants in WNT7B disrupt the development of multiple organs in humans. Journal of Medical Genetics. 60(3):294-300
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Martin, M., Vermeiren, S., Bostaille, N., Eubelen, M., Spitzer, D., Vermeersch, M., Profaci, C.P., Pozuelo, E., Toussay, X., Raman-Nair, J., Tebabi, P., America, M., De Groote, A., Sanderson, L.E., Cabochette, P., Germano, R.F.V., Torres, D., Boutry, S., de Kerchove d'Exaerde, A., Bellefroid, E.J., Phoenix, T.N., Devraj, K., Lacoste, B., Daneman, R., Liebner, S., Vanhollebeke, B. (2022) Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science (New York, N.Y.). 375:eabm4459
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Sun, H., Chen, M., Wang, Z., Zhao, G., Liu, J.X. (2019) Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Environmental pollution (Barking, Essex : 1987). 256:113364
- Eubelen, M., Bostaille, N., Cabochette, P., Gauquier, A., Tebabi, P., Dumitru, A.C., Koehler, M., Gut, P., Alsteens, D., Stainier, D.Y.R., Garcia-Pino, A., Vanhollebeke, B. (2018) A molecular mechanism for Wnt ligand-specific signaling. Science (New York, N.Y.). 361(6403):
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Grainger, S., Richter, J., Palazón, R.E., Pouget, C., Lonquich, B., Wirth, S., Grassme, K.S., Herzog, W., Swift, M.R., Weinstein, B.M., Traver, D., Willert, K. (2016) Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Reports. 17:1595-1606
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