ZFIN is now using GRCz12tu for Genomic Data
Gene
spx
- ID
- ZDB-GENE-041210-158
- Name
- spexin hormone
- Symbol
- spx Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable neuropeptide hormone activity; type 2 galanin receptor binding activity; and type 3 galanin receptor binding activity. Involved in cholesterol homeostasis; glucose homeostasis; and triglyceride homeostasis. Acts upstream of or within negative regulation of eating behavior. Located in nucleus. Is expressed in several structures, including central nervous system; digestive system; female organism; male organism; and pleuroperitoneal region. Orthologous to human SPX (spexin hormone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Zheng et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf2090 | Allele with one delins | Exon 2 | Frameshift | TALEN |
1 - 1 of 1
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR028126 | Spexin |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | Spexin |
|---|---|---|---|
| UniProtKB:F1QQI2 | InterPro | 102 | |
| UniProtKB:A0AB13ABP1 | InterPro | 102 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(5xUAS:spx-2A-mCherry) |
| 1 | Jeong et al., 2019 | ||
| Tg(spx:GAL4) |
|
| 1 | Kim et al., 2019 | |
| Tg(spx:mCherry-CAAX) |
|
| 1 | (2) |
1 - 3 of 3
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-13I19 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423858 (1) | 1032 nt | ||
| Genomic | GenBank:BX649476 (1) | 126315 nt | ||
| Polypeptide | UniProtKB:A0AB13ABP1 (1) | 102 aa |
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
- Jeong, I., Kim, E., Seong, J.Y., Park, H.C. (2019) Overexpression of Spexin 1 in the Dorsal Habenula Reduces Anxiety in Zebrafish. Frontiers in neural circuits. 13:53
- Kim, E., Jeong, I., Chung, A.Y., Kim, S., Kwon, S.H., Seong, J.Y., Park, H.C. (2019) Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish CNS. Scientific Reports. 9:5025
- Marvel, M.M., Spicer, O.S., Wong, T.T., Zmora, N., Zohar, Y. (2019) Knockout of Gnrh2 in zebrafish (Danio rerio) reveals its roles in regulating feeding behavior and oocyte quality. General and comparative endocrinology. 280:15-23
- Safian, D., Bogerd, J., Schulz, R.W. (2019) Regulation of spermatogonial development by Fsh: the complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. General and comparative endocrinology. 284:113244
- Marvel, M., Spicer, O.S., Wong, T.T., Zmora, N., Zohar, Y. (2018) Knockout of the Gnrh genes in zebrafish: effects on reproduction and potential compensation by reproductive and feeding-related neuropeptides. Biology of reproduction. 99(3):565-577
- Pandey, S., Shekhar, K., Regev, A., Schier, A.F. (2018) Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq. Current biology : CB. 28(7):1052-1065.e7
- Zheng, B., Li, S., Liu, Y., Li, Y., Chen, H., Tang, H., Liu, X., Lin, H., Zhang, Y., Cheng, C.H.K. (2017) Spexin Suppress Food Intake in Zebrafish: Evidence from Gene Knockout Study. Scientific Reports. 7:14643
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 10 of 13
Show