Gene

srgap1b

ID

ZDB-GENE-041210-103

Name

SLIT-ROBO Rho GTPase activating protein 1b

Symbol

srgap1b Nomenclature History

Previous Names

srgap2b
si:ch211-125a15.2

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have Rac GTPase binding activity. Predicted to be involved in negative regulation of cell migration. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in thyroid gland papillary carcinoma. Orthologous to human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With srgap1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
thyroid gland follicular carcinoma	Alliance	{Thyroid cancer, nonmedullary, 2}	188470

Associated With srgap1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000198	Rho GTPase-activating protein domain
Domain	IPR001060	FCH domain
Domain	IPR001452	SH3 domain
Domain	IPR031160	F-BAR domain
Domain	IPR037451	SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR027267	AH/BAR domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily