Gene
ncf4
- ID
- ZDB-GENE-041124-1
- Name
- neutrophil cytosolic factor 4
- Symbol
- ncf4 Nomenclature History
- Previous Names
-
- p40phox (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to act upstream of or within phagocytosis and respiratory burst. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 3 and rheumatoid arthritis. Orthologous to human NCF4 (neutrophil cytosolic factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu789 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive chronic granulomatous disease 3 | Alliance | Chronic granulomatous disease 3, autosomal recessive | 613960 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NADPH Oxidase and PX Domain-Containing | Neutrophil cytosol factor 4, PX domain | Neutrophil cytosol factor P40 | Neutrophil cytosol factor P40, PB1 domain | Neutrophil cytosol factor P40, SH3 domain | PB1 domain | PB1-like domain | Phox homology | PX domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LUW2 | InterPro | 355 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-232H18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-261D11 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-85D7 | ZFIN Curated Data | |
| Encodes | EST | eu789 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193589 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193606 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205711 (1) | 2216 nt | ||
| Genomic | GenBank:BX571946 (1) | 179796 nt | ||
| Polypeptide | UniProtKB:Q1LUW2 (1) | 355 aa |
- Zasu, A., Hishima, F., Thauvin, M., Yoneyama, Y., Kitani, Y., Hakuno, F., Volovitch, M., Takahashi, S.I., Vriz, S., Rampon, C., Kamei, H. (2022) NADPH-Oxidase Derived Hydrogen Peroxide and Irs2b Facilitate Re-oxygenation-Induced Catch-Up Growth in Zebrafish Embryo. Frontiers in endocrinology. 13:929668
- Gu, W., Liu, S., Chen, L., Liu, Y., Gu, C., Ren, H.Q., Wu, B. (2020) Single-cell RNA sequencing reveals size-dependent effects of polystyrene microplastics on immune and secretory cell populations from zebrafish intestines. Environmental science & technology. 54(6):3417-3427
- Le Faou, P., Völkel, P., and Angrand, P.O. (2011) The zebrafish genes encoding the Polycomb Repressive Complex (PRC) 1. Gene. 475(1):10-21
- Kawahara, T., and Lambeth, J.D. (2007) Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evolutionary Biology. 7:178
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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