Gene

vtnb

ID

ZDB-GENE-041116-1

Name

vitronectin b

Symbol

vtnb Nomenclature History

Previous Names

vtn

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable extracellular matrix binding activity and integrin binding activity. Predicted to be involved in cell adhesion mediated by integrin and cell-matrix adhesion. Predicted to act upstream of or within immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in hypothalamus; liver; liver primordium; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907751 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vtnb Human Ortholog

No data available

Associated With vtnb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000585	Hemopexin-like domain
Domain	IPR001212	Somatomedin B domain
Domain	IPR020436	Somatomedin B domain, chordata
Family	IPR051298	Heme transport and cell adhesion protein
Homologous_superfamily	IPR036024	Somatomedin B-like domain superfamily
Homologous_superfamily	IPR036375	Hemopexin-like domain superfamily
Repeat	IPR018487	Hemopexin-like repeats