Gene
slc7a6os
- ID
- ZDB-GENE-041114-32
- Name
- solute carrier family 7 member 6 opposite strand
- Symbol
- slc7a6os Nomenclature History
- Previous Names
-
- im:7137677
- zgc:103493
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Acts upstream of or within midbrain-hindbrain boundary structural organization and somite development. Predicted to be located in cytoplasm and nucleus. Is expressed in axis; central nervous system; eye; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to human SLC7A6OS (solute carrier family 7 member 6 opposite strand).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Benini et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Epilepsy, progressive myoclonic, 12 | 619191 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Probable RNA polymerase II nuclear localization protein SLC7A6OS | Transcription factor Iwr1 domain |
|---|---|---|---|---|
| UniProtKB:F1QEZ3 | InterPro | 328 | ||
| UniProtKB:Q5U3I2 | InterPro | 326 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc7a6os-201
(1)
|
Ensembl | 1,505 nt | ||
| mRNA |
slc7a6os-202
(1)
|
Ensembl | 1,803 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-181F22 | ZFIN Curated Data | |
| Encodes | EST | fq36d09 | Rauch et al., 2003 | |
| Encodes | EST | IMAGE:7137677 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:103493 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192413 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007344 (1) | 1520 nt | ||
| Genomic | GenBank:CU464087 (1) | 155817 nt | ||
| Polypeptide | UniProtKB:F1QEZ3 (1) | 328 aa |
- Benini, A., Cignarella, F., Calvarini, L., Mantovanelli, S., Giacopuzzi, E., Zizioli, D., Borsani, G. (2015) slc7a6os Gene Plays a Critical Role in Defined Areas of the Developing CNS in Zebrafish. PLoS One. 10:e0119696
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kawakami, A., Nojima, Y., Toyoda, A., Takahoko, M., Satoh, M., Tanaka, H., Wada, H., Masai, I., Terasaki, H., Sakaki, Y., Takeda, H., and Okamoto, H. (2005) The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Current biology : CB. 15(5):480-488
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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