prdm12b

ID

ZDB-GENE-041114-172

Name

PR domain containing 12b

Symbol

prdm12b Nomenclature History

Previous Names

zgc:101606

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable histone methyltransferase binding activity. Predicted to be involved in neurogenesis and regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including basal plate midbrain region; central nervous system; cranial ganglion; ectoderm; and midbrain neural keel. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 8. Orthologous to human PRDM12 (PR/SET domain 12).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:101606 (25 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prdm12b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 8	Alliance	Neuropathy, hereditary sensory and autonomic, type VIII	616488

Associated With prdm12b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001214	SET domain
Domain	IPR013087	Zinc finger C2H2-type
Domain	IPR044406	PRDM12, PR/SET domain
Family	IPR017126	PR-domain zinc finger protein PRDM12
Family	IPR050331	Zinc finger PRDM4/PRDM1/PRDM14-like
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily
Homologous_superfamily	IPR046341	SET domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q5U3V3	InterPro	366
UniProtKB:A0AC58JIQ0	InterPro	483
UniProtKB:A0AC58JIQ5	InterPro	483
UniProtKB:A0AC58JIQ6	InterPro	483
UniProtKB:A0AC58JIQ9	InterPro	366
UniProtKB:A0AC58JIR0	InterPro	429
UniProtKB:A0AC58JIR1	InterPro	483
UniProtKB:A0AC58JIR2	InterPro	429
UniProtKB:A0AC58JIR3	InterPro	429
UniProtKB:A0AC58JIR5	InterPro	429
UniProtKB:A0AC58JIR6	InterPro	366
UniProtKB:A0AC58JIR7	InterPro	429
UniProtKB:A0AC58JIR8	InterPro	254
UniProtKB:A0AC58JIR9	InterPro	366
UniProtKB:A0AC58JIS0	InterPro	254
UniProtKB:A0AC58JIS1	InterPro	366
UniProtKB:A0AC58JIS2	InterPro	366
UniProtKB:A0AC58JIS3	InterPro	366
UniProtKB:A0AC58JIS4	InterPro	366
UniProtKB:A0AC58JIS5	InterPro	254
UniProtKB:A0AC58JIS6	InterPro	366
UniProtKB:A0AC58JIS7	InterPro	366
UniProtKB:A0AC58JIS8	InterPro	366
UniProtKB:A0AC58JIS9	InterPro	366
UniProtKB:A0AC58JIT0	InterPro	429
UniProtKB:A0AC58JIT1	InterPro	254
UniProtKB:A0AC58JIT2	InterPro	366
UniProtKB:A0AC58JIT3	InterPro	254
UniProtKB:A0AC58JIT4	InterPro	254
UniProtKB:A0AC58JIT5	InterPro	254
UniProtKB:A0AC58JIT6	InterPro	254
UniProtKB:A0AC58JIT7	InterPro	254
UniProtKB:A0AC58JIT8	InterPro	254
UniProtKB:A0AC58JIT9	InterPro	254
UniProtKB:A0AC58JIU1	InterPro	254
UniProtKB:A0AC58JIU2	InterPro	254
UniProtKB:A0AC58JIU3	InterPro	254
UniProtKB:A0AC58JIU4	InterPro	366
UniProtKB:A0AC58JIU5	InterPro	254
UniProtKB:A0AC58JIU6	InterPro	254
UniProtKB:A0AC58JIU7	InterPro	254
UniProtKB:A0AC58JIV1	InterPro	254
UniProtKB:A0AC58JIV2	InterPro	254
UniProtKB:A0AC58JIV3	InterPro	254
UniProtKB:A0AC58JIV8	InterPro	254
UniProtKB:A0AC58JIW0	InterPro	254