Gene
irf1b
- ID
- ZDB-GENE-041114-13
- Name
- interferon regulatory factor 1b
- Symbol
- irf1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Acts upstream of or within regulation of defense response to virus and response to virus. Located in nucleus. Is expressed in several structures, including cardiovascular system; eye; liver; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 117; lung cancer (multiple); smallpox; and stomach cancer (multiple). Orthologous to human IRF1 (interferon regulatory factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu922 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb81 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
| ihb85 | Allele with one insertion | Unknown | Unknown | not specified | |
| ihb112 | Allele with one delins | Exon 1 | Splice Site | CRISPR | |
| la014106Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa37387 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-irf1b | (3) | |
| MO1-irf1b | N/A | Bielczyk-Maczyńska et al., 2014 |
| MO2-irf1b | N/A | Fan et al., 2014 |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 117 | Alliance | Immunodeficiency 117, mycobacteriosis, autosomal recessive | 620668 |
| lung cancer | Alliance | Nonsmall cell lung cancer, somatic | 211980 |
| stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
1 - 3 of 3
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019817 | Interferon regulatory factor, conserved site |
| Domain | IPR001346 | Interferon regulatory factor, DNA-binding domain |
| Family | IPR017431 | Interferon regulatory factor-1/2 |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Interferon regulatory factor-1/2 | Interferon regulatory factor, conserved site | Interferon regulatory factor, DNA-binding domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q6E6 | InterPro | 286 | |||||
| UniProtKB:Q6TGZ2 | InterPro | 287 | |||||
| UniProtKB:A0AB32T9S6 | InterPro | 258 | |||||
| UniProtKB:A0AB32TAJ9 | InterPro | 220 | |||||
| UniProtKB:A0A8M1PKC4 | InterPro | 287 |
1 - 5 of 5
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-25G7 | ZFIN Curated Data | |
| Encodes | EST | eu922 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:103566 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192360 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205747 (1) | 1894 nt | ||
| Genomic | GenBank:CU302316 (2) | 166312 nt | ||
| Polypeptide | UniProtKB:A0A8M1PKC4 (1) | 287 aa |
- Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
- Lin, Y., Li, H., Zheng, S., Han, R., Wu, K., Tang, S., Zhong, X., Chen, J. (2024) Elucidating tobacco smoke-induced craniofacial deformities: Biomarker and MAPK signaling dysregulation unraveled by cross-species multi-omics analysis. Ecotoxicology and environmental safety. 288:117343117343
- Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L.C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A.H.Y., Schofield, C.J., von Kriegsheim, A., Marsh, J.A., Pavet, V., Sansom, O.J., Illingworth, R.S., Patton, E.E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports. 43:114406114406
- Grabinski, S.E., Parsana, D., Perkins, B.D. (2023) Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways. Frontiers in molecular neuroscience. 16:11488401148840
- Torraca, V., White, R.J., Sealy, I.M., Mazon-Moya, M., Duggan, G., Willis, A., Busch-Nentwich, E.M., Mostowy, S. (2023) Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri. Disease models & mechanisms. 17(1):
- Wu, J., Li, J., Chen, K., Liu, G., Zhou, Y., Chen, W., Zhu, X., Ni, T.T., Zhang, B., Jin, D., Li, D., Kang, L., Wu, Y., Zhu, P., Xie, P., Zhong, T.P. (2023) Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2209062120e2209062120
- An, L.L., Zhao, X., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., Guo, W.H., Dan, C., Gui, J.F., Zhang, Y.B. (2022) Promoter Binding and Nuclear Retention Features of Zebrafish IRF Family Members in IFN Response. Frontiers in immunology. 13:861262
- Cai, H., Chen, Y., Feng, Y., Asadi, M., Kaufman, L., Lee, K., Kehrer, T., Miorin, L., Garcia-Sastre, A., Gusella, G.L., Gu, L., Ni, Z., Mou, S., He, J.C., Zhou, W. (2022) SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation. Molecular therapy : the journal of the American Society of Gene Therapy. 31(3):774-787
- Chen, S.N., Gan, Z., Hou, J., Yang, Y.C., Huang, L., Huang, B., Wang, S., Nie, P. (2022) Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Nature communications. 13:999
- Jiang, J., Gu, J., Zhan, A., Mao, M., Liu, Y., Wang, H., Mao, Y. (2022) Cloning, Exogenous Expression and Function Analysis of Interferon-γ from Gadus macrocephalus. Viruses. 14(10):
1 - 10 of 48
Show