Gene

colec11

ID

ZDB-GENE-041114-11

Name

collectin sub-family member 11

Symbol

colec11 Nomenclature History

Previous Names

wu:fb82e09
zgc:103572

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable several functions, including calcium ion binding activity; calcium-dependent carbohydrate binding activity; and monosaccharide binding activity. Involved in developmental process. Acts upstream of or within neural crest cell migration. Predicted to be located in extracellular region and membrane. Predicted to be part of collagen trimer. Predicted to be active in extracellular space. Is expressed in head; hindbrain; liver; pronephric duct; and pronephric glomerulus. Used to study cleft palate. Human ortholog(s) of this gene implicated in 3MC syndrome 2. Orthologous to human COLEC11 (collectin subfamily member 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Rooryck et al., 2011

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Rooryck et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With colec11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
3MC syndrome 2	Alliance	3MC syndrome 2	265050

Associated With colec11 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cleft palate	WT + MO1-colec11 + MO2-colec11	standard conditions	Rooryck et al., 2011

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018378	C-type lectin, conserved site
Domain	IPR001304	C-type lectin-like
Domain	IPR033990	Collectin, C-type lectin-like domain
Family	IPR051077	Calcium-dependent Lectin
Homologous_superfamily	IPR016186	C-type lectin-like/link domain superfamily
Homologous_superfamily	IPR016187	C-type lectin fold
Repeat	IPR008160	Collagen triple helix repeat

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q5U3G1	InterPro	271
UniProtKB:A0A8M3AK08	InterPro	277
UniProtKB:A0AB32T5I8	InterPro	290
UniProtKB:A0AB32T611	InterPro	284
UniProtKB:A0AB32TAZ8	InterPro	278