Gene
fgf13a
- ID
- ZDB-GENE-041114-101
- Name
- fibroblast growth factor 13a
- Symbol
- fgf13a Nomenclature History
- Previous Names
-
- fgf13
- zgc:101784
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable sodium channel regulator activity. Predicted to be involved in neurogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including basal plate midbrain region; caudal fin; heart; nervous system; and trigeminal placode. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 90 and non-syndromic X-linked intellectual disability. Orthologous to human FGF13 (fibroblast growth factor 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101784 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012564Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018969Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn0168Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| pfu5 | Allele with one deletion | Exon 5 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fgf13a | Varshney et al., 2015 | |
| CRISPR2-fgf13a | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 90 | Alliance | Developmental and epileptic encephalopathy 90 | 301058 |
| Intellectual developmental disorder, X-linked 110 | 301095 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|---|
| UniProtKB:A0A8M9PZ61 | InterPro | 199 | ||
| UniProtKB:Q5TKR2 | InterPro | 246 | ||
| UniProtKB:Q5U3Q2 | InterPro | 193 | ||
| UniProtKB:E7F5G0 | InterPro | 255 | ||
| UniProtKB:A0AB32T422 | InterPro | 263 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fgf13a-201
(1)
|
Ensembl | 1,371 nt | ||
| mRNA |
fgf13a-202
(1)
|
Ensembl | 1,130 nt | ||
| mRNA |
fgf13a-203
(1)
|
Ensembl | 2,383 nt | ||
| mRNA |
fgf13a-204
(1)
|
Ensembl | 646 nt | ||
| mRNA |
fgf13a-205
(1)
|
Ensembl | 659 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-51P7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-79C4 | ZFIN Curated Data | |
| Contained in | BAC | CH211-253P10 | ||
| Contained in | BAC | DKEY-124I15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101784 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192347 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007399 (1) | 1999 nt | ||
| Genomic | GenBank:BX004988 (1) | 166194 nt | ||
| Polypeptide | UniProtKB:A0AB32T422 (1) | 263 aa |
- Tuttle, A.M., Miller, L.N., Royer, L.J., Wen, H., Kelly, J.J., Calistri, N.L., Heiser, L.M., Nechiporuk, A.V. (2024) Single-cell analysis of Rohon-Beard neurons implicates Fgf signaling in axon maintenance and cell survival. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(16):
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Martin, K.E., Ravisankar, P., Beerens, M., MacRae, C.A., Waxman, J.S. (2023) Nr2f1a maintains atrial nkx2.5 expression to repress pacemaker identity within venous atrial cardiomyocytes of zebrafish. eLIFE. 12:
- Lencer, E., Prekeris, R., Artinger, K.B. (2021) Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives. eLIFE. 10:
- Hawkey-Noble, A., Umali, J., Fowler, G., French, C.R. (2020) Expression of three P4- phospholipid Flippases-atp11a, atp11b, and atp11c in zebrafish (Danio rerio). Gene expression patterns : GEP. 36:119115
- Burczyk, M.S., Burkhalter, M.D., Tena, T.C., Grisanti, L.A., Kauk, M., Matysik, S., Donow, C., Kustermann, M., Rothe, M., Cui, Y., Raad, F., Laue, S., Moretti, A., Zimmermann, W.H., Wess, J., Kühl, M., Hoffmann, C., Tilley, D.G., Philipp, M. (2019) Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish. JCI insight. 4(20):
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Minhas, R., Paterek, A., Łapiński, M., Bazała, M., Korzh, V., Winata, C.L. (2019) A novel conserved enhancer at zebrafish zic3 and zic6 loci drives neural expression. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(9):837-849
- Heid, J., Cencioni, C., Ripa, R., Baumgart, M., Atlante, S., Milano, G., Scopece, A., Kuenne, C., Guenther, S., Azzimato, V., Farsetti, A., Rossi, G., Braun, T., Pompilio, G., Martelli, F., Zeiher, A.M., Cellerino, A., Gaetano, C., Spallotta, F. (2017) Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health. Scientific Reports. 7:16839
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