Gene
mlip
- ID
- ZDB-GENE-041111-277
- Name
- muscular LMNA-interacting protein
- Symbol
- mlip Nomenclature History
- Previous Names
-
- im:7151231
- si:ch211-163p8.1
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Is expressed in heart; heart tube; and myotome. Orthologous to human MLIP (muscular LMNA interacting protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151231 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mlip | Lin et al., 2025 | |
| CRISPR2-mlip | Lin et al., 2025 | |
| CRISPR3-mlip | Lin et al., 2025 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis | 620138 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR029331 | Muscular LMNA-interacting protein |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Muscular LMNA-interacting protein |
|---|---|---|---|
| UniProtKB:A0A8M3B7S3 | InterPro | 1117 | |
| UniProtKB:A0A8M1Q1Z8 | InterPro | 317 | |
| UniProtKB:A0A8M3AYS2 | InterPro | 1118 | |
| UniProtKB:A0A8M9QNK8 | InterPro | 1081 | |
| UniProtKB:A0AB32T6J7 | InterPro | 450 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-344J23 | ||
| Contained in | BAC | CH211-163P8 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7151231 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009307054 (1) | 3538 nt | ||
| Genomic | GenBank:CU571255 (2) | 80442 nt | ||
| Polypeptide | UniProtKB:A0A8M3AYS2 (1) | 1118 aa |
- Lin, S.J., Huang, K., Petree, C., Qin, W., Varshney, P., Varshney, G.K. (2025) Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic acids research. 53:
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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