Gene
trip12
- ID
- ZDB-GENE-041111-262
- Name
- thyroid hormone receptor interactor 12
- Symbol
- trip12 Nomenclature History
- Previous Names
-
- im:7149446
- si:ch211-272f3.4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including chromatin remodeling; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in myotome. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149446 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Clark-Baraitser syndrome | Alliance | Intellectual developmental disorder, autosomal dominant 49 | 617752 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000569 | HECT domain |
| Domain | IPR004170 | WWE domain |
| Domain | IPR018123 | WWE domain, subgroup |
| Family | IPR045322 | E3 ubiquitin-protein ligase HECTD1/TRIP12-like |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR037197 | WWE domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | E3 ubiquitin-protein ligase HECTD1/TRIP12-like | HECT domain | HECT, E3 ligase catalytic domain | WWE domain | WWE domain, subgroup | WWE domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RCR6 | InterPro | 2026 | ||||||||
| UniProtKB:A0A8M2B5R0 | InterPro | 2054 | ||||||||
| UniProtKB:A0A8M1P4D4 | InterPro | 2053 | ||||||||
| UniProtKB:A0A8M2B655 | InterPro | 2096 | ||||||||
| UniProtKB:A0A8M9PA43 | InterPro | 1666 | ||||||||
| UniProtKB:A0A8M2B5U3 | InterPro | 2095 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trip12-201
(1)
|
Ensembl | 7,723 nt | ||
| mRNA |
trip12-202
(1)
|
Ensembl | 258 nt | ||
| mRNA |
trip12-203
(1)
|
Ensembl | 6,552 nt |
Interactions and Pathways
No data available
Plasmids
No data available