Gene
mylkb
- ID
- ZDB-GENE-041111-150
- Name
- myosin light chain kinase b
- Symbol
- mylkb Nomenclature History
- Previous Names
-
- im:7142009
- mlck1b (1)
- si:dkey-226n16.2
- unm_sa1486
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in brain and myotome. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; coronary artery disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Tournoij et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thoracic aortic aneurysm | Alliance | Aortic aneurysm, familial thoracic 7 | 613780 |
| Megacystis-microcolon-intestinal hypoperistalsis syndrome 1 | 249210 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FDK2 | InterPro | 966 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-226N16 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7142009 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009302263 (1) | 9051 nt | ||
| Genomic | GenBank:CR853290 (1) | 196624 nt | ||
| Polypeptide | UniProtKB:E7FDK2 (1) | 966 aa |
- Comparative Orthology
- Alliance
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Figueroa, R.J., Carrasco-Avino, G., Wichmann, I.A., Lange, M., Owen, G.I., Siekmann, A.F., Corvalán, A.H., Opazo, J.C., Amigo, J.D. (2017) Reprimo tissue-specific expression pattern is conserved between zebrafish and human. PLoS One. 12:e0178274
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lambert, M.J., Olsen, K.G., Cooper, C.D. (2014) Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish. Gene. 546(2):271-6
- Tournoij, E., Weber, G.J., Akkerman, J.W., de Groot, P.G., Zon, L.I., Moll, F.L., and Schulte-Merker, S. (2010) Mlck1a is expressed in zebrafish thrombocytes and an essential component for thrombus formation. Journal of thrombosis and haemostasis : JTH. 8(3):588-595
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