Gene
map2k2a
- ID
- ZDB-GENE-041027-1
- Name
- mitogen-activated protein kinase kinase 2a
- Symbol
- map2k2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in several cellular components, including endosome; focal adhesion; and mitochondrion. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1108 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cardiofaciocutaneous syndrome 4 | Alliance | Cardiofaciocutaneous syndrome 4 | 615280 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR050915 | MAP kinase kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | MAP kinase kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LY62 | InterPro | 397 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map2k2a-201
(1)
|
Ensembl | 3,193 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(cyt1:map2k2a_S219D-GFP) |
|
| 1 | Chou et al., 2015 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195M2 | ZFIN Curated Data | |
| Encodes | EST | eu1108 | Thisse et al., 2005 | |
| Encodes | EST | fa56c06 | ||
| Encodes | cDNA | MGC:123171 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001037391 (1) | 2787 nt | ||
| Genomic | GenBank:BX088720 (1) | 190269 nt | ||
| Polypeptide | UniProtKB:Q1LY62 (1) | 397 aa |
- Wu, Z., Shi, Y., Cui, Y., Xing, X., Zhang, L., Liu, D., Zhang, Y., Dong, J., Jin, L., Pang, M., Xiao, R.P., Zhu, Z., Xiong, J.W., Tong, X., Zhang, Y., Wang, S., Tang, F., Zhang, B. (2023) Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration. Protein & cell. 14:350368350-368
- Ogawa, Y., Shiraki, T., Fukada, Y., Kojima, D. (2021) Foxq2 determines blue cone identity in zebrafish. Science advances. 7:eabi9784
- Zhang, X., Zhou, Q., Li, X., Zou, W., Hu, X. (2020) Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Environmental pollution (Barking, Essex : 1987). 263:114473
- Zhou, Z., Zheng, L., Tang, C., Chen, Z., Zhu, R., Peng, X., Wu, X., Zhu, P. (2020) Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Frontiers in Physiology. 11:565307
- Mo, Z.Q., Han, R., Wang, J.L., Ni, L.Y., Su, Y.L., Lai, X.L., He, Z.C., Chen, H.P., Li, Y.W., Sun, H.Y., Luo, X.C., Dan, X.M. (2018) Characterization and functional analysis of grouper (Epinephelus coioides) MEK1 and MEK2. Fish & shellfish immunology. 84:1090-1097
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Liu, P., Zhong, T.P. (2017) MAPK/ERK signalling is required for zebrafish cardiac regeneration. Biotechnology Letters. 39(7):1069-1077
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Sertori, R., Liongue, C., Basheer, F., Lewis, K.L., Rasighaemi, P., de Coninck, D., Traver, D., Ward, A.C. (2016) Conserved IL-2Rγc Signaling Mediates Lymphopoiesis in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 196(1):135-43
- Yuan, Y., Zhang, J., Zhou, Q. (2016) Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43:99-102
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