Gene
tent4b
- ID
- ZDB-GENE-041021-2
- Name
- terminal nucleotidyltransferase 4B
- Symbol
- tent4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing and polyadenylation-dependent ncRNA catabolic process. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in ovary and testis. Orthologous to human TENT4B (terminal nucleotidyltransferase 4B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kamminga et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12807 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21014 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21015 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21016 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31582 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40953 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotidyltransferase superfamily | Nucleotidyltransferase Trf4-like | PAP/25A-associated | Poly(A) RNA polymerase, mitochondrial-like, central palm domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QH41 | InterPro | 383 | ||||
| UniProtKB:A0A1D6UPT1 | InterPro | 653 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tent4b-201
(1)
|
Ensembl | 3,910 nt | ||
| ncRNA |
papd5-002
(1)
|
Ensembl | 535 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-14I19 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001326696 (1) | 4085 nt | ||
| Genomic | GenBank:BX663605 (1) | 170764 nt | ||
| Polypeptide | UniProtKB:A0A1D6UPT1 (1) | 653 aa |
- Comparative Orthology
- Alliance
- Chang, H., Yeo, J., Kim, J.G., Kim, H., Lim, J., Lee, M., Kim, H.H., Ohk, J., Jeon, H.Y., Lee, H., Jung, H., Kim, K.W., Kim, V.N. (2018) Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos. Molecular Cell. 70:72-82.e7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kamminga, L.M., Luteijn, M.J., den Broeder, M.J., Redl, S., Kaaij, L.J., Roovers, E.F., Ladurner, P., Berezikov, E., and Ketting, R.F. (2010) Hen1 is required for oocyte development and piRNA stability in zebrafish. The EMBO journal. 29(21):3688-3700
- Dildrop, R., and Ruther, U. (2004) Organization of Iroquois genes in fish. Development genes and evolution. 214(6):267-276
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