ZFIN is now using GRCz12tu for Genomic Data
Gene
dll4
- ID
- ZDB-GENE-041014-73
- Name
- delta-like 4 (Drosophila)
- Symbol
- dll4 Nomenclature History
- Previous Names
-
- si:ch211-244p18.5
- zgc:136596
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Notch binding activity. Involved in negative regulation of sprouting angiogenesis. Acts upstream of or within several processes, including negative regulation of blood vessel endothelial cell migration; vasculature development; and ventral spinal cord interneuron differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including atrioventricular canal endocardium; brain; caudal hematopoietic tissue; vasculature; and xanthophore. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL4 (delta like canonical Notch ligand 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 71 figures from 57 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 26 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Adams-Oliver syndrome 6 | 616589 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011651 | Notch ligand, N-terminal domain |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Notch ligand, N-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1ECY3 | InterPro | 683 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers