Gene
trdn
- ID
- ZDB-GENE-041014-193
- Name
- triadin
- Symbol
- trdn Nomenclature History
- Previous Names
-
- si:dkey-72g4.2
- zgc:162523
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within regulation of heart contraction. Predicted to be located in sarcoplasmic reticulum membrane. Predicted to be active in junctional sarcoplasmic reticulum membrane and plasma membrane. Is expressed in adaxial cell; cardiovascular system; musculature system; somite; and yolk syncytial layer. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia and catecholaminergic polymorphic ventricular tachycardia 5. Orthologous to human TRDN (triadin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6894188 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Vecchi et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa6647 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa10783 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa10815 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa11135 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa15309 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-trdn | N/A | Musso et al., 2014 |
MO2-trdn | N/A | Vecchi et al., 2021 |
MO3-trdn | N/A | Vecchi et al., 2021 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
catecholaminergic polymorphic ventricular tachycardia 5 | Alliance | Cardiac arrhythmia syndrome, with or without skeletal muscle weakness | 615441 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR010798 | Triadin |
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Domain Details Per Protein
Protein | Additional Resources | Length | Triadin |
---|---|---|---|
UniProtKB:A3KNU6 | InterPro | 226 | |
UniProtKB:Q5XJD2 | InterPro | 535 | |
UniProtKB:Q32LR2 | InterPro | 376 | |
UniProtKB:A0A8M6YWT4 | InterPro | 981 | |
UniProtKB:A0A8M9P313 | InterPro | 1063 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-138K5 | ZFIN Curated Data | |
Contained in | BAC | DKEY-72G4 | ZFIN Curated Data | |
Encodes | EST | IMAGE:6894188 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:162523 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001089561 (1) | 1035 nt | ||
Genomic | GenBank:CR381614 (1) | 153083 nt | ||
Polypeptide | UniProtKB:A0AB32TCM8 (1) | 1135 aa |
- Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., Luo, S. (2022) α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Frontiers in pharmacology. 13:802917
- Vecchi, V.M., Spreafico, M., Brix, A., Santoni, A., Sala, S., Pistocchi, A., Marozzi, A., Di Resta, C. (2021) Generation of a Triadin KnockOut Syndrome Zebrafish Model. International Journal of Molecular Sciences. 22(18):
- Frank, D.F., Miller, G.W., Connon, R.E., Geist, J., Lein, P.J. (2017) Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. PeerJ. 5:e4106
- Sanchez, N.E., Harty, B.L., O'Reilly-Pol, T., Ackerman, S.D., Herbert, A.L., Holmgren, M., Johnson, S.L., Gray, R.S., Monk, K.R. (2017) Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda). 7(10):3415-3425
- Musso, G., Tasan, M., Mosimann, C., Beaver, J.E., Plovie, E., Carr, L.A., Chua, H.N., Dunham, J., Zuberi, K., Rodriguez, H., Morris, Q., Zon, L., Roth, F.P., and MacRae, C.A. (2014) Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development (Cambridge, England). 141(1):224-235
- Kinoshita, S., Katsumi, E., Yamamoto, H., Takeuchi, K., and Watabe, S. (2011) Molecular and Functional Analyses of Aspolin, a Fish-Specific Protein Extremely Rich in Aspartic Acid. Marine biotechnology (New York, N.Y.). 13(3):517-526
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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