Gene
ccl38.6
- ID
- ZDB-GENE-041014-165
- Name
- chemokine (C-C motif) ligand 38, duplicate 6
- Symbol
- ccl38.6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable chemokine activity. Predicted to act upstream of or within chemotaxis and immune response. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including IgA vasculitis; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Orthologous to several human genes including CCL2 (C-C motif chemokine ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021623Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CC chemokine, conserved site | Chemokine beta/gamma/delta | Chemokine interleukin-8-like domain | Chemokine interleukin-8-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:F8W4J0 | InterPro | |||||
| UniProtKB:Q5TYP6 | InterPro | 103 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ccl38.6-201
(1)
|
Ensembl | 501 nt | ||
| mRNA |
ccl38.6-202
(1)
|
Ensembl | 616 nt | ||
| mRNA |
ccl38.6-203
(1)
|
Ensembl | 1,036 nt | ||
| mRNA |
ccl38.6-204
(1)
|
Ensembl | 849 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-59A8 | ZFIN Curated Data | |
| Encodes | EST | fj16d01 | ||
| Encodes | cDNA | MGC:171246 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083080 (1) | 626 nt | ||
| Genomic | GenBank:BX957287 (1) | 154419 nt | ||
| Polypeptide | UniProtKB:Q5TYP6 (1) | 103 aa |
No data available
- Zhou, T., Li, N., Jin, Y., Zeng, Q., Prabowo, W., Liu, Y., Tian, C., Bao, L., Liu, S., Yuan, Z., Fu, Q., Gao, S., Gao, D., Dunham, R., Shubin, N.H., Liu, Z. (2018) Chemokine C-C motif ligand 33 is a key regulator of teleost fish barbel development. Proceedings of the National Academy of Sciences of the United States of America. 115(22):E5018-E5027
- Carmona, S.J., Teichmann, S.A., Ferreira, L., Macaulay, I.C., Stubbington, M.J., Cvejic, A., Gfeller, D. (2017) Single-cell transcriptome analysis of fish immune cells provides insight into the evolution of vertebrate immune cell types. Genome research. 27(3):451-461
- Garg, A.D., Vandenberk, L., Fang, S., Fasche, T., Van Eygen, S., Maes, J., Van Woensel, M., Koks, C., Vanthillo, N., Graf, N., de Witte, P., Van Gool, S., Salven, P., Agostinis, P. (2017) Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing. Cell death and differentiation. 24:832-843
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- Nomiyama, H., Osada, N., and Yoshie, O. (2013) Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history. Genes to cells : devoted to molecular & cellular mechanisms. 18(1):1-16
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Nomiyama, H., Hieshima, K., Osada, N., Kato-Unoki, Y., Otsuka-Ono, K., Takegawa, S., Izawa, T., Yoshizawa, A., Kikuchi, Y., Tanase, S., Miura, R., Kusuda, J., Nakao, M., and Yoshie, O. (2008) Extensive Expansion and Diversification of the Chemokine Gene Family in Zebrafish: Identification of a Novel Chemokine Subfamily CX. BMC Genomics. 9(1):222
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Devries, M.E., Kelvin, A.A., Xu, L., Ran, L., Robinson, J., and Kelvin, D.J. (2006) Defining the origins and evolution of the chemokine/chemokine receptor system. Journal of immunology (Baltimore, Md. : 1950). 176(1):401-415
- Peatman, E., and Liu, Z. (2006) CC chemokines in zebrafish: Evidence for extensive intrachromosomal gene duplications. Genomics. 88(3):381-385
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