Gene

galk1

ID

ZDB-GENE-041010-79

Name

galactokinase 1

Symbol

galk1 Nomenclature History

Previous Names

zgc:101541

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have galactokinase activity. Predicted to be involved in galactose catabolic process via UDP-galactose. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in cataract and galactokinase deficiency. Orthologous to human GALK1 (galactokinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:101541 (1 image)
IMAGE:7159382 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With galk1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
galactokinase deficiency	Alliance	Galactokinase deficiency with cataracts	230200

Associated With galk1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR006203	GHMP kinase, ATP-binding, conserved site
Conserved_site	IPR019741	Galactokinase, conserved site
Domain	IPR006204	GHMP kinase N-terminal domain
Domain	IPR013750	GHMP kinase, C-terminal domain
Domain	IPR019539	Galactokinase, N-terminal domain
Family	IPR000705	Galactokinase
Family	IPR006206	Mevalonate/galactokinase
Homologous_superfamily	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Homologous_superfamily	IPR020568	Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily	IPR036554	GHMP kinase, C-terminal domain superfamily