Gene
paxip1
- ID
- ZDB-GENE-041010-214
- Name
- PAX interacting (with transcription-activation domain) protein 1
- Symbol
- paxip1 Nomenclature History
- Previous Names
-
- fa04b06
- wu:fa04b06
- zgc:92593 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Orthologous to human PAXIP1 (PAX interacting protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa5145 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9641 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17872 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32936 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32937 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39846 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | DNA Damage Response and Transcriptional Regulator |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9QII6 | InterPro | 1136 | |||
| UniProtKB:Q5XIY8 | InterPro | 943 | |||
| UniProtKB:F1Q5Z1 | InterPro | 1122 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
paxip1-201
(1)
|
Ensembl | 4,529 nt | ||
| mRNA |
paxip1-202
(1)
|
Ensembl | 3,757 nt | ||
| mRNA |
paxip1-203
(1)
|
Ensembl | 4,637 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207D6 | ZFIN Curated Data | |
| Encodes | EST | fa04b06 | ||
| Encodes | EST | IMAGE:7165510 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92593 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005929 (1) | 3757 nt | ||
| Genomic | GenBank:CR855328 (2) | 152638 nt | ||
| Polypeptide | UniProtKB:A0A8M9QII6 (1) | 1136 aa |
- Tsai, Y.W., Jeng, K.S., He, M.K., Hsieh, Y.W., Lai, H.H., Lai, C.Y., Huang, C.C., Chang, C.F., Huang, C.T., Her, G.M. (2021) MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis. Cells. 10(12):
- Zhong, Y., Duan, C. (2017) Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Frontiers in endocrinology. 7:174
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhang, H., Wang, X., Lv, K., Gao, S., Wang, G., Fan, C., Zhang, X.A., Yan, J. (2015) Time Point-based Integrative Analyses of Deep-transcriptome Identify Four Signal Pathways in Blastemal Regeneration of Zebrafish Lower Jaw. Stem cells (Dayton, Ohio). 33(3):806-18
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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