Gene
rad51c
- ID
- ZDB-GENE-041010-204
- Name
- RAD51 paralog C
- Symbol
- rad51c Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent DNA damage sensor activity. Predicted to contribute to crossover junction DNA endonuclease activity and four-way junction DNA binding activity. Acts upstream of or within blood coagulation; erythrocyte homeostasis; and leukocyte homeostasis. Predicted to be located in nucleus. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex and Rad51C-XRCC3 complex. Predicted to be active in replication fork. Is expressed in telencephalon. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101596 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group O | Alliance | Fanconi anemia, complementation group O | 613390 |
| {Breast-ovarian cancer, familial, susceptibility to, 3} | 613399 |
1 - 2 of 2
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Fanconi anemia | rad51chg65/hg65 (NHGRI-1) | standard conditions | Raman et al., 2021 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013632 | DNA recombination and repair protein Rad51-like, C-terminal |
| Domain | IPR020588 | DNA recombination and repair protein RecA-like, ATP-binding domain |
| Family | IPR016467 | DNA recombination and repair protein, RecA-like |
| Family | IPR052093 | Homologous Recombination Repair Mediator |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | DNA recombination and repair protein Rad51-like, C-terminal | DNA recombination and repair protein, RecA-like | DNA recombination and repair protein RecA-like, ATP-binding domain | Homologous Recombination Repair Mediator | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QC24 | InterPro | 362 | ||||||
| UniProtKB:A0A8M9QKP1 | InterPro | 337 | ||||||
| UniProtKB:Q5XJT2 | InterPro | 362 |
1 - 3 of 3
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rad51c-201
(1)
|
Ensembl | 1,743 nt | ||
| mRNA |
rad51c-202
(1)
|
Ensembl | 1,638 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available