Gene

rad51c

ID

ZDB-GENE-041010-204

Name

RAD51 paralog C

Symbol

rad51c Nomenclature History

Previous Names

fanco (1)
zgc:101596 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to contribute to crossover junction endodeoxyribonuclease activity and four-way junction DNA binding activity. Predicted to be involved in DNA repair and reciprocal meiotic recombination. Predicted to colocalize with Holliday junction resolvase complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group O and hereditary breast ovarian cancer syndrome. Orthologous to human RAD51C (RAD51 paralog C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:101596 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Ramanagoudr-Bhojappa et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rad51c Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fanconi anemia complementation group O	Alliance	Fanconi anemia, complementation group O	613390
		{Breast-ovarian cancer, familial, susceptibility to, 3}	613399

Associated With rad51c Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR013632	DNA recombination and repair protein Rad51-like, C-terminal
Domain	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain
Family	IPR016467	DNA recombination and repair protein, RecA-like
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase