Gene
cldn5b
- ID
- ZDB-GENE-041010-140
- Name
- claudin 5b
- Symbol
- cldn5b Nomenclature History
- Previous Names
-
- zgc:103419
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including brain; cardiovascular system; head; pleuroperitoneal region; and ventral mesoderm. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CLDN5 (claudin 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103419 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bonkhofer et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Claudin | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|---|
| UniProtKB:F1R5J2 | InterPro | 220 | |||
| UniProtKB:A0A2R8Q6I0 | InterPro | 217 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cldn5b-201
(1)
|
Ensembl | 1,647 nt | ||
| mRNA |
cldn5b-202
(1)
|
Ensembl | 661 nt |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-122A17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103419 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192214 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001006044 (1) | 1661 nt | ||
| Genomic | GenBank:CR384089 (1) | 92630 nt | ||
| Polypeptide | UniProtKB:F1R5J2 (1) | 220 aa |
- Campbell, P.D., Lee, I., Thyme, S., Granato, M. (2023) Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. Molecular psychiatry. 28(9):3769-3781
- O'Brown, N.M., Patel, N.B., Hartmann, U., Klein, A.M., Gu, C., Megason, S.G. (2023) The secreted neuronal signal spock1 promotes blood-brain barrier development. Developmental Cell. 58(17):1534-1547.e6
- Pellegrini, E., Fernezelian, D., Malleret, C., Gueguen, M.M., Patche-Firmin, J., Rastegar, S., Meilhac, O., Diotel, N. (2023) Estrogenic regulation of claudin 5 and tight junction protein 1 gene expression in zebrafish: A role on blood-brain barrier?. The Journal of comparative neurology. 531(17):1828-1845
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Deshwar, A.R., Cytrynbaum, C., Murthy, H., Zon, J., Chitayat, D., Volpatti, J., Newbury-Ecob, R., Ellard, S., Lango Allen, H., Yu, E.P., Noche, R., Walker, S., Scherer, S.W., Mahida, S., Elitt, C.M., Nicolas, G., Goldenberg, A., Saugier-Veber, P., Lecoquierre, F., Dabaj, I., Meddaugh, H., Marble, M., Keppler-Noreuil, K.M., Drayson, L., Barañano, K.W., Chassevent, A., Agre, K., Létard, P., Bilan, F., Le Guyader, G., Laquerrière, A., Ramsey, K., Henderson, L., Brady, L., Tarnopolsky, M., Bainbridge, M., Friedman, J., Capri, Y., Athayde, L., Kok, F., Gurgel-Giannetti, J., Ramos, L.L.P., Blaser, S., Dowling, J.J., Weksberg, R. (2022) Variants in CLDN5 cause a syndrome characterized by seizures, microcephaly and brain calcifications. Brain : a journal of neurology. 146(6):2285-2297
- Gurung, S., Restrepo, N.K., Chestnut, B., Klimkaite, L., Sumanas, S. (2022) Single-cell transcriptomic analysis of vascular endothelial cells in zebrafish embryos. Scientific Reports. 12:13065
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
- Mu, X., Qi, S., Wang, H., Yuan, L., Wang, C., Li, Y., Qiu, J. (2022) Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response. Environment International. 165:107287
- Paulissen, E., Martin, B.L. (2022) Myogenic regulatory factors myod and Myf5 are required for dorsal aorta formation and angiogenic sprouting. Developmental Biology. 490:134-143
- Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L. (2022) Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLIFE. 11:
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