Gene
pawr
- ID
- ZDB-GENE-041010-108
- Name
- PRKC, apoptosis, WT1, regulator
- Symbol
- pawr Nomenclature History
- Previous Names
-
- pawrl
- PAR-4 (1)
- zgc:103513
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Acts upstream of or within regulation of vascular permeability. Predicted to be active in actin filament and cytoplasm. Is expressed in several structures, including alar plate midbrain region; anterior axial hypoblast; nervous system; polster; and solid lens vesicle. Orthologous to human PAWR (pro-apoptotic WT1 regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103513 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa40291 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pawr | N/A | Acharya et al., 2011 |
| MO2-pawr | N/A | Acharya et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026117 | Prostate apoptosis response 4 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Prostate apoptosis response 4 |
|---|---|---|---|
| UniProtKB:Q5XJ95 | InterPro | 305 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28J4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-210E13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103513 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191251 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001006015 (1) | 2277 nt | ||
| Genomic | GenBank:BX511298 (1) | 217817 nt | ||
| Polypeptide | UniProtKB:Q5XJ95 (1) | 305 aa |
- Flinn, M.A., Otten, C., Brandt, Z.J., Bostrom, J.R., Kenarsary, A., Wan, T.C., Auchampach, J.A., Abdelilah-Seyfried, S., O'Meara, C.C., Link, B.A. (2020) Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development (Cambridge, England). 147(16):
- Flinn, M.A., Jeffery, B.E., O'Meara, C.C., Link, B.A. (2018) Yap is Required for Scar Formation but not Myocyte Proliferation During Heart Regeneration in Zebrafish. Cardiovascular research. 115(3):570-577
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Miesfeld, J.B., Gestri, G., Clark, B.S., Flinn, M.A., Poole, R.J., Bader, J.R., Besharse, J.C., Wilson, S.W., Link, B.A. (2015) Yap and Taz regulate retinal pigment epithelial cell fate. Development (Cambridge, England). 142(17):3021-32
- Carr, B.W., Basepayne, T.L., Chen, L., Jayashankar, V., Weiser, D.C. (2014) Characterization of the Zebrafish Homolog of Zipper Interacting Protein Kinase. International Journal of Molecular Sciences. 15:11597-11613
- Acharya, M., Huang, L., Fleisch, V.C., Allison, W.T., and Walter, M.A. (2011) A Complex Regulatory Network of Transcription Factors Critical for Ocular Development and Disease. Human molecular genetics. 20(8):1610-24
- Shoval, Y., Pietrokovski, S., and Kimchi, A. (2007) ZIPK: A Unique Case of Murine-Specific Divergence of a Conserved Vertebrate Gene. PLoS Genetics. 3(10):e180
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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