Gene
usp4
- ID
- ZDB-GENE-041008-187
- Name
- ubiquitin specific peptidase 4 (proto-oncogene)
- Symbol
- usp4 Nomenclature History
- Previous Names
-
- im:7139722
- unpEL (1)
- wu:fa11d11
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within convergent extension; negative regulation of toll-like receptor signaling pathway; and protein deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human USP4 (ubiquitin specific peptidase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139722 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-usp4 | N/A | Tse et al., 2009 |
| MO2-usp4 | N/A | (2) |
| MO3-usp4 | N/A | Zhou et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR006615 | Peptidase C19, ubiquitin-specific peptidase, DUSP domain |
| Domain | IPR028135 | Ubiquitin-like domain, USP-type |
| Domain | IPR029346 | Ubiquitin carboxyl-terminal hydrolase, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DUSP-like superfamily | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Peptidase C19, ubiquitin-specific peptidase, DUSP domain | Ubiquitin carboxyl-terminal hydrolase | Ubiquitin carboxyl-terminal hydrolase, C-terminal | Ubiquitin-like domain, USP-type | Ubiquitin specific protease, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7EZD6 | InterPro | 1009 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-178O3 | ZFIN Curated Data | |
| Encodes | EST | fa11d11 | ||
| Encodes | EST | IMAGE:7139722 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002662510 (1) | 4588 nt | ||
| Genomic | GenBank:BX957236 (1) | 211391 nt | ||
| Polypeptide | UniProtKB:E7EZD6 (1) | 1009 aa |
- Zhou, F., Xie, F., Jin, K., Zhang, Z., Clerici, M., Gao, R., van Dinther, M., Sixma, T.K., Huang, H., Zhang, L., Ten Dijke, P. (2017) USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling. The EMBO journal. 36(11):1623-1639
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Vlasschaert, C., Xia, X., Coulombe, J., Gray, D.A. (2015) Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11. BMC Evolutionary Biology. 15:230
- Ren, L., Tan, X.J., Xiong, Y.F., Xu, K., Zhou, Y., Zhong, H., Liu, Y., Hong, Y., Liu, S.J. (2014) Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Gene. 552(2):265-71
- Zhou, F., Zhang, X., Dam, H.V., Dijke, P.T., Huang, H., and Zhang, L. (2012) Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation. The Journal of biological chemistry. 287(14):11002-11010
- Tse, W.K., Eisenhaber, B., Ho, S.H., Ng, Q., Eisenhaber, F., and Jiang, Y.J. (2009) Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics. 10:637
- Titus, T.A., Selvig, D.R., Qin, B., Wilson, C., Starks, A.M., Roe, B.A., and Postlethwait, J.H. (2006) The Fanconi anemia gene network is conserved from zebrafish to human. Gene. 371(2):211-223
- Taylor, M.R., Kikkawa, S., Diez-Juan, A., Ramamurthy, V., Kawakami, K., Carmeliet, P., and Brockerhoff, S.E. (2005) The Zebrafish pob Gene Encodes a Novel Protein Required for Survival of Red Cone Photoreceptor Cells. Genetics. 170(1):263-273
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