grin2da

ID

ZDB-GENE-041008-124

Name

glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a

Symbol

grin2da Nomenclature History

Previous Names

NR2D.2 (1)
im:7137805 (1)
si:dkey-154b17.1

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable NMDA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in presumptive neural retina; retina; and somite. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 46. Orthologous to human GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7137805 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grin2da Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 46	Alliance	Developmental and epileptic encephalopathy 46	617162

Associated With grin2da Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor, C-terminal
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family	IPR001508	Ionotropic glutamate receptor, metazoa
Family	IPR015683	Ionotropic glutamate receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:I3NI77	InterPro	1916
UniProtKB:A0AC58I027	InterPro	1918
UniProtKB:A0AC58I030	InterPro	1918
UniProtKB:A0AC58I031	InterPro	1918
UniProtKB:A0AC58I032	InterPro	1918
UniProtKB:A0AC58I038	InterPro	1916
UniProtKB:A0AC58I039	InterPro	1916
UniProtKB:A0AC58I040	InterPro	1916
UniProtKB:A0AC58I041	InterPro	1547
UniProtKB:A0AC58I042	InterPro	1916
UniProtKB:A0AC58I045	InterPro	1918
UniProtKB:A0AC58I051	InterPro	1916
UniProtKB:A0AC58I052	InterPro	1916
UniProtKB:A0AC58I059	InterPro	1918