Gene

xrcc5

ID
ZDB-GENE-041008-108
Name
X-ray repair complementing defective repair in Chinese hamster cells 5
Symbol
xrcc5 Nomenclature History
Previous Names
  • im:7137560
  • Ku80 (1)
  • si:ch211-239d11.4
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to contribute to double-stranded DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of apoptotic process; and response to ionizing radiation. Predicted to localize to Ku70:Ku80 complex and nuclear chromosome, telomeric region. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Is expressed in several structures, including blastomere; central nervous system; cloaca; presumptive neural retina; and pronephric duct. Orthologous to human XRCC5 (X-ray repair cross complementing 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With xrcc5 Human Ortholog
No data available
Associated With xrcc5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002035 von Willebrand factor, type A
Domain IPR005160 Ku70/Ku80 C-terminal arm
Domain IPR005161 Ku70/Ku80, N-terminal alpha/beta
Domain IPR006164 Ku70/Ku80 beta-barrel domain
Domain IPR014893 Ku, C-terminal
Family IPR024193 Ku80
Homologous_superfamily IPR016194 SPOC-like, C-terminal domain superfamily
Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
Homologous_superfamily IPR036494 Ku, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Ku70/Ku80 beta-barrel domain Ku70/Ku80 C-terminal arm Ku70/Ku80, N-terminal alpha/beta Ku80 Ku, C-terminal Ku, C-terminal domain superfamily SPOC-like, C-terminal domain superfamily von Willebrand factor A-like domain superfamily von Willebrand factor, type A
UniProtKB:A0A0R4IB13 727
UniProtKB:Q5FY48 727
UniProtKB:A4FUM7 727
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations