Gene

drc1

ID

ZDB-GENE-041001-218

Name

dynein regulatory complex subunit 1 homolog (Chlamydomonas)

Symbol

drc1 Nomenclature History

Previous Names

ccdc164
sb:eu1661
si:dkey-65b13.6

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to localize to axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 21. Is expressed in Kupffer's vesicle; axis; basal plate midbrain region; nervous system; and pronephric duct. Orthologous to human DRC1 (dynein regulatory complex subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu1661 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With drc1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary ciliary dyskinesia 21	Alliance	Ciliary dyskinesia, primary, 21	615294
		Spermatogenic failure 80	620222

Associated With drc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR029440	Dynein regulatory complex protein 1, C-terminal
Domain	IPR039505	Dynein regulatory complex protein 1/2, N-terminal
Family	IPR039750	Dynein regulatory complex protein