Gene

stxbp5a

ID

ZDB-GENE-041001-161

Name

syntaxin binding protein 5a (tomosyn)

Symbol

stxbp5a Nomenclature History

Previous Names

stxbp5
si:ch211-279m15.2

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have several functions, including GTPase activator activity; Rab GTPase binding activity; and syntaxin binding activity. Predicted to be involved in regulation of exocytosis and regulation of protein secretion. Predicted to localize to SNARE complex and plasma membrane. Orthologous to human STXBP5 (syntaxin binding protein 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zhu et al., 2022

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stxbp5a Human Ortholog

No data available

Associated With stxbp5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013577	Lethal giant larvae homologue 2
Domain	IPR042855	v-SNARE, coiled-coil homology domain
Family	IPR000664	Lethal(2) giant larvae protein
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Lethal(2) giant larvae protein	Lethal giant larvae homologue 2	v-SNARE, coiled-coil homology domain	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M3ALK2 InterPro	1095
UniProtKB:A0A8M3AKV9 InterPro	1142
UniProtKB:Q5RGD1 InterPro	1128
UniProtKB:A0A8M3B457 InterPro	1126
UniProtKB:A0A8M9PHB6 InterPro	1109

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	stxbp5a-201 (1) Ensembl	Havana	656 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	stxbp5a-202 (1) Ensembl	Havana	746 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	stxbp5a-203 (1) Ensembl	Havana	7176 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations