Gene
pygb
- ID
- ZDB-GENE-040928-2
- Name
- phosphorylase, glycogen; brain
- Symbol
- pygb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable glycogen phosphorylase activity and pyridoxal phosphate binding activity. Predicted to be involved in glycogen catabolic process. Predicted to act upstream of or within glycogen metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including eye; gill; heart; integument; and pleuroperitoneal region. Orthologous to human PYGB (glycogen phosphorylase B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cruz et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17951 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycogen/starch/alpha-glucan phosphorylase | Glycosyl transferase, family 35 | Phosphorylase pyridoxal-phosphate attachment site |
|---|---|---|---|---|---|
| UniProtKB:A4IG19 | InterPro | 843 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-67N1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162102 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212809 (1) | 3596 nt | ||
| Genomic | GenBank:AL929290 (1) | 168517 nt | ||
| Polypeptide | UniProtKB:A4IG19 (1) | 843 aa |
- Antomagesh, F., Jayakumar Rajeswari, J., Vijayan, M.M. (2023) Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle. General and comparative endocrinology. 336:114231
- Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D., Singh, S.P. (2022) In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology (Baltimore, Md.). 77(3):789-801
- Tang, S.L., Liang, X.F., He, S., Li, L., Alam, M.S., Wu, J. (2022) Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Frontiers in genetics. 13:909091
- Blanco, A.M., Bertucci, J.I., Hatef, A., Unniappan, S. (2020) Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Scientific Reports. 10:10727
- Rajeswari, J.J., Blanco, A.M., Unniappan, S. (2020) Phoenixin-20 (PNX-20) Suppresses Food Intake, Modulates Glucoregulatory Enzymes, and Enhances Glycolysis in Zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 318(5):R917-R928
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hu, P., Liu, M., Liu, Y., Wang, J., Zhang, D., Niu, H., Jiang, S., Wang, J., Zhang, D., Han, B., Xu, Q., Chen, L. (2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952
- Chen, K., Cole, R.B., and Rees, B.B. (2013) Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. Journal of proteomics. 78:477-485
- Cruz, S.A., Tseng, Y.C., Kaiya, H., Hwang, P.P., Cruz, S.A., Hwang, P.P., Kaiya, H., Tseng, Y.C., and Hwang, P.P. (2010) Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 156(2):190-200
- Ung, C.Y., Lam, S.H., Hlaing, M.M., Winata, C.L., Korzh, S., Mathavan, S., and Gong, Z. (2010) Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. BMC Genomics. 11:212
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