Gene
cnot3a
- ID
- ZDB-GENE-040927-6
- Name
- CCR4-NOT transcription complex, subunit 3a
- Symbol
- cnot3a Nomenclature History
- Previous Names
-
- fb73b06
- fc17h07
- wu:fb73b06
- wu:fc17h07
- zgc:92813
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Acts upstream of or within digestive tract development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including gut; head; heart; integument; and testis. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Delacruz et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Delacruz et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| uab307 | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with speech delay, autism, and dysmorphic facies | 618672 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007207 | CCR4-Not complex component, Not N-terminal domain |
| Domain | IPR007282 | NOT2/NOT3/NOT5, C-terminal |
| Family | IPR012270 | CCR4-NOT complex, subunit 3/ 5 |
| Family | IPR040168 | Not2/Not3/Not5 |
| Homologous_superfamily | IPR038635 | CCR4-NOT complex subunit 2/3/5, C-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CCR4-Not complex component, Not N-terminal domain | CCR4-NOT complex subunit 2/3/5, C-terminal domain superfamily | CCR4-NOT complex, subunit 3/ 5 | Not2/Not3/Not5 | NOT2/NOT3/NOT5, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:E9QGK5 | InterPro | 901 | |||||
| UniProtKB:F1Q4L8 | InterPro | 908 | |||||
| UniProtKB:A0A8M9P7W2 | InterPro | 906 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cnot3a-201
(1)
|
Ensembl | 4,220 nt | ||
| mRNA |
cnot3a-203
(1)
|
Ensembl | 4,198 nt | ||
| ncRNA |
cnot3a-003
(1)
|
Ensembl | 634 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328118 (1) | 4220 nt | ||
| Genomic | GenBank:CR854927 (1) | 217399 nt | ||
| Polypeptide | UniProtKB:F1Q4L8 (1) | 908 aa |
- Delacruz, R.G.C., Sandoval, I.T., Chang, K., Miller, B.N., Reyes-Uribe, L., Borras, E., Lynch, P.M., Taggart, M.W., Hawk, E.T., Vilar, E., Jones, D.A. (2019) Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas. Oncotarget. 10:3939-3951
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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