Gene

cnot1

ID
ZDB-GENE-040915-1
Name
CCR4-NOT transcription complex, subunit 1
Symbol
cnot1 Nomenclature History
Previous Names
  • cdc39-like (1)
  • im:7141761
  • kiaa1007l (1)
  • wu:fc58h04
  • zgc:152902
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have estrogen receptor binding activity; molecular adaptor activity; and retinoic acid receptor binding activity. Involved in developmental growth. Predicted to localize to CCR4-NOT core complex and P-body. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cnot1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Holoprosencephaly 12, with or without pancreatic agenesis 618500
Vissers-Bodmer syndrome 619033
Associated With cnot1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR007196 CCR4-Not complex component, Not1, C-terminal
Domain IPR024557 CCR4-NOT transcription complex subunit 1, domain 4
Domain IPR032191 CCR4-NOT transcription complex subunit 1, CAF1-binding domain
Domain IPR032193 CCR4-NOT transcription complex subunit 1, TTP binding domain
Domain IPR032194 CCR4-NOT transcription complex subunit 1, HEAT repeat
Family IPR040398 CCR4-NOT transcription complex subunit 1
Homologous_superfamily IPR038535 CCR4-NOT subunit 1, TTP binding domain superfamily
Domain Details Per Protein
Protein Length CCR4-Not complex component, Not1, C-terminal CCR4-NOT subunit 1, TTP binding domain superfamily CCR4-NOT transcription complex subunit 1 CCR4-NOT transcription complex subunit 1, CAF1-binding domain CCR4-NOT transcription complex subunit 1, domain 4 CCR4-NOT transcription complex subunit 1, HEAT repeat CCR4-NOT transcription complex subunit 1, TTP binding domain
UniProtKB:A1A5H6 2374
UniProtKB:F1R160 293
UniProtKB:A0A2R8QE33 2331
UniProtKB:F1QFA6 2374
UniProtKB:D6QWT8 41
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations