ZFIN is now using GRCz12tu for Genomic Data
Gene
gtf3c3
- ID
- ZDB-GENE-040914-80
- Name
- general transcription factor IIIC, polypeptide 3
- Symbol
- gtf3c3 Nomenclature History
- Previous Names
-
- im:7136784
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C3 (general transcription factor IIIC subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136784 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Abdel-Hamid et al., 2025
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gtf3c3 | Abdel-Hamid et al., 2025 | |
| CRISPR2-gtf3c3 | Abdel-Hamid et al., 2025 | |
| CRISPR3-gtf3c3 | Abdel-Hamid et al., 2025 | |
| CRISPR4-gtf3c3 | Sun et al., 2019 | |
| TALEN1-gtf3c3 | Xiao et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures | 621201 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | Transcription factor Tfc4/TFIIIC-102/Sfc4 |
|---|---|---|---|---|---|
| UniProtKB:F1RDA7 | InterPro | 918 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gtf3c3-201
(1)
|
Ensembl | 2,932 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | IMAGE:7136784 | Thisse et al., 2004 |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256242 (1) | 2932 nt | ||
| Genomic | GenBank:LO018629 (1) | 98774 nt | ||
| Polypeptide | UniProtKB:F1RDA7 (1) | 918 aa |
- Abdel-Hamid, M.S., Paimboeuf, A., Zaki, M.S., Figueiredo, F., Abdel-Ghafar, S.F., Maher, S., Friðriksdóttir, R., Sulem, P., Högnason, H.B., Hallgrímsdóttir, S., Rojas, C.F.N., Kok, F., Suri, M., Alves, C.A.P.F., Houlden, H., Maroofian, R., Patten, S.A. (2025) Biallelic variants in GTF3C3 encoding a subunit of the TFIIIC2 complex are associated with neurodevelopmental phenotypes in humans and zebrafish. Brain communications. 7:fcaf055fcaf055
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic acids research. 41(14):e141
- Hart, D.O., Raha, T., Lawson, N.D., and Green, M.R. (2007) Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Nature. 450(7172):1082-1085
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