Gene

adprs

ID

ZDB-GENE-040912-85

Name

ADP-ribosylserine hydrolase

Symbol

adprs Nomenclature History

Previous Names

adprhl2
fj36e06 (1)
wu:fj36e06 (1)
zgc:92867 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable O-acetyl-ADP-ribose deacetylase activity; hydrolase activity, acting on glycosyl bonds; and magnesium ion binding activity. Predicted to be involved in DNA repair; negative regulation of necroptotic process; and peptidyl-serine ADP-deribosylation. Predicted to be located in site of DNA damage. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7143915 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
CRISPR1-adprs		Varshney et al., 2015
CRISPR2-adprs		Varshney et al., 2015

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Human Disease

Associated With adprs Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
stress-induced childhood-onset neurodegeneration with variable ataxia and seizures	Alliance	Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures	618170

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Associated With adprs Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR005502	ADP-ribosylation/Crystallin J1
Family	IPR050792	ADP-ribosylglycohydrolase
Homologous_superfamily	IPR036705	ADP-ribosylation/Crystallin J1 superfamily

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Domain Details Per Protein

Protein	Additional Resources	Length	ADP-ribosylation/Crystallin J1	ADP-ribosylation/Crystallin J1 superfamily	ADP-ribosylglycohydrolase
UniProtKB:Q66HT8	InterPro	370
UniProtKB:A0A8M3ARH3	InterPro	203

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 17

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	adprhl2-201 (1) Ensembl	Ensembl		1,615 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-13P1	CT027705	ZFIN Curated Data
Encodes	EST	fj36e06	AW077462 AW077704
Encodes	EST	IMAGE:7143915	CK681922	Thisse et al., 2004
Encodes	cDNA	MGC:92867	BC081683	ZFIN Curated Data
Encodes	cDNA	MGC:173786	BC152161	ZFIN Curated Data
Encodes	cDNA	MGC:191352	BC164177	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001004565 (1)	1614 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR854917 (1)	259326 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:Q66HT8 (1)	370 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	ADPRS	1	Ensembl:ENSG00000116863 Gene:54936 HGNC:21304 OMIM:610624	Amino acid sequence comparison (1) Phylogenetic tree (1)
Mouse	Adprs	4	Ensembl:ENSMUSG00000042558 Gene:100206 MGI:2140364	Amino acid sequence comparison (1) Phylogenetic tree (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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