ZFIN is now using GRCz12tu for Genomic Data
Gene
fth1b
- ID
- ZDB-GENE-040912-30
- Name
- ferritin, heavy polypeptide 1b
- Symbol
- fth1b Nomenclature History
- Previous Names
-
- zgc:92245 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hemochromatosis type 5 and neurodegeneration with brain iron accumulation. Orthologous to human FTH1 (ferritin heavy chain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hemochromatosis type 5 | Alliance | ?Hemochromatosis, type 5 | 615517 |
| Neurodegeneration with brain iron accumulation 9 | 620669 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ferritin | Ferritin, conserved site | Ferritin/DPS domain | Ferritin-like | Ferritin-like diiron domain | Ferritin-like superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q66HX7 | InterPro | 177 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-296I8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92245 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004562 (1) | 1462 nt | ||
| Genomic | GenBank:CU651670 (2) | 38908 nt | ||
| Polypeptide | UniProtKB:Q66HX7 (1) | 177 aa |
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Chandrapalan, T., Kwong, R.W.M. (2020) Influence of dietary iron exposure on trace metal homeostasis and expression of metal transporters during development in zebrafish☆. Environmental pollution (Barking, Essex : 1987). 261:114159
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
- Hassan, A.T., Kwong, R.W.M. (2020) The neurophysiological effects of iron in early life stages of zebrafish. Environmental pollution (Barking, Essex : 1987). 267:115625
- Garcia-Reyero, N., Escalon, L., Prats, E., Faria, M., Soares, A.M., Raldúa, D. (2016) Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Bulletin of environmental contamination and toxicology. 96(6):707-713
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Feng, G., Long, Y., Peng, J., Li, Q., Cui, Z. (2015) Transcriptomic characterization of the dorsal lobes after hepatectomy of the ventral lobe in zebrafish. BMC Genomics. 16:979
- Liu, H., Takano, T., Peatman, E., Abernathy, J., Wang, S., Sha, Z., Kucuktas, H., Xu, D.H., Klesius, P., and Liu, Z. (2010) Molecular characterization and gene expression of the channel catfish ferritin H subunit after bacterial infection and iron treatment. Journal of experimental zoology. Part A, Ecological genetics and physiology. 313(6):359-368
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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