ZFIN is now using GRCz12tu for Genomic Data
Gene
bmpr1ab
- ID
- ZDB-GENE-040912-150
- Name
- bone morphogenetic protein receptor, type IAb
- Symbol
- bmpr1ab Nomenclature History
- Previous Names
-
- alk3b (1)
- wu:fe05b06
- wu:fe06e10
- zgc:92227
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable transforming growth factor beta receptor activity, type I. Acts upstream of or within BMP signaling pathway; circulatory system development; and dorsal/ventral pattern formation. Predicted to be located in membrane. Predicted to be part of signaling receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blastoderm; blastodisc; cardinal system; margin; and ovarian follicle. Human ortholog(s) of this gene implicated in hamartoma; hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Little et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary mixed polyposis syndrome 2 | Alliance | Polyposis syndrome, hereditary mixed, 2 | 610069 |
| juvenile polyposis syndrome | Alliance | Polyposis, juvenile intestinal | 174900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000472 | Activin types I and II receptor domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003605 | GS domain |
| Family | IPR000333 | Ser/Thr protein kinase, TGFB receptor |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR045860 | Snake toxin-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Activin types I and II receptor domain | GS domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain | Ser/Thr protein kinase, TGFB receptor | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q66HY1 | InterPro | 534 | |||||||||
| UniProtKB:A0A8M1N2A7 | InterPro | 535 | |||||||||
| UniProtKB:A0AC58GVB1 | InterPro | 503 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bmpr1ab-201
(1)
|
Ensembl | 3,258 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers