Gene
coasy
- ID
- ZDB-GENE-040912-137
- Name
- CoA synthase
- Symbol
- coasy Nomenclature History
- Previous Names
-
- zgc:92337
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Predicted to be involved in coenzyme A biosynthetic process. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia. Is expressed in liver; muscle; nervous system; and somite. Orthologous to human COASY (Coenzyme A synthase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Khatri et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Khatri et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodegeneration with brain iron accumulation 6 | Alliance | Neurodegeneration with brain iron accumulation 6 | 615643 |
| pontocerebellar hypoplasia type 12 | Alliance | Pontocerebellar hypoplasia, type 12 | 618266 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytidyltransferase-like domain | Dephospho-CoA kinase | P-loop containing nucleoside triphosphate hydrolase | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|
|
UniProtKB:Q66HW0
|
554 |
Interactions and Pathways
No data available
Plasmids
No data available