Gene
slc51a
- ID
- ZDB-GENE-040912-10
- Name
- solute carrier family 51 member A
- Symbol
- slc51a Nomenclature History
- Previous Names
-
- fb57f06
- wu:fb57f06
- zgc:92111
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable protein heterodimerization activity; protein homodimerization activity; and transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport. Predicted to act upstream of or within lipid transport. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in membrane. Is expressed in liver; pancreas; pancreas primordium; and pancreatic bud. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SLC51A (solute carrier family 51 member A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92111 (1 image)
- IMAGE:7159529 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37896 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Cholestasis, progressive familial intrahepatic, 6 | 619484 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR005178 | Organic solute transporter subunit alpha/Transmembrane protein 184 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Organic solute transporter subunit alpha/Transmembrane protein 184 |
|---|---|---|---|
| UniProtKB:Q66I08 | InterPro | 326 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc51a-201
(1)
|
Ensembl | 1,648 nt | ||
| ncRNA |
slc51a-002
(1)
|
Ensembl | 754 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-11P10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-227M20 | ZFIN Curated Data | |
| Encodes | EST | fb57f06 | ||
| Encodes | EST | IMAGE:7159529 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92111 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004546 (1) | 1607 nt | ||
| Genomic | GenBank:CR383672 (1) | 231583 nt | ||
| Polypeptide | UniProtKB:Q66I08 (1) | 326 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | SLC51A | 3 | Amino acid sequence comparison (2) |
- Shi, W., Yi, X., Ruan, H., Wang, D., Wu, D., Jiang, P., Luo, L., Ma, X., Jiang, F., Li, C., Wu, W., Luo, L., Li, L., Wang, G., Qiu, J., Huang, H. (2025) An animal model recapitulates human hepatic diseases associated with GATA6 mutations. Proceedings of the National Academy of Sciences of the United States of America. 122:e2317801121e2317801121
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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