Gene
xrcc1
- ID
- ZDB-GENE-040822-30
- Name
- X-ray repair complementing defective repair in Chinese hamster cells 1
- Symbol
- xrcc1 Nomenclature History
- Previous Names
-
- zgc:91996
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable damaged DNA binding activity. Predicted to be involved in base-excision repair. Predicted to act upstream of or within double-strand break repair via nonhomologous end joining and single strand break repair. Predicted to be located in chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); central nervous system cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 26 | Alliance | ?Spinocerebellar ataxia, autosomal recessive 26 | 617633 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | DNA-repair protein Xrcc1, N-terminal | Galactose-binding-like domain superfamily | XRCC1, first (central) BRCT domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q68EG6 | InterPro | 615 | |||||
| UniProtKB:F1QXI2 | InterPro | 617 |
Interactions and Pathways
No data available
Plasmids
No data available