Gene
negr1
- ID
- ZDB-GENE-040822-27
- Name
- neuronal growth regulator 1
- Symbol
- negr1 Nomenclature History
- Previous Names
-
- zgc:100871
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in plasma membrane and side of membrane. Is expressed in head; midbrain neural rod; nervous system; and otic vesicle. Orthologous to human NEGR1 (neuronal growth regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141308 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-negr1 | (2) | |
| CRISPR2-negr1 | (2) | |
| CRISPR3-negr1 | Thyme et al., 2019 | |
| CRISPR4-negr1 | Thyme et al., 2019 | |
| CRISPR5-negr1 | Mazzaferro et al., 2025 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | IgLON domain-containing protein | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B3I9 | InterPro | 360 | ||||||||
| UniProtKB:A0A4W4 | InterPro | 346 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-255N14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-242M17 | ZFIN Curated Data | |
| Contained in | BAC | RP71-80I17 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7141308 | Thisse et al., 2004 | |
| Encodes | cDNA | cssl:d814 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:100871 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003851 (1) | 2455 nt | ||
| Genomic | GenBank:BX324166 (1) | 215450 nt | ||
| Polypeptide | UniProtKB:A0A8M3B3I9 (1) | 360 aa |
- Mazzaferro, E., Mujica, E., Zhang, H., Emmanouilidou, A., Jenseit, A., Evcimen, B., Metzendorf, C., Dethlefsen, O., Loos, R.J., Vienberg, S.G., Larsson, A., Allalou, A., den Hoed, M. (2025) Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning. Scientific Reports. 15:54085408
- Habicher, J., Sanvido, I., Bühler, A., Sartori, S., Piccoli, G., Carl, M. (2024) The Risk Genes for Neuropsychiatric Disorders negr1 and opcml Are Expressed throughout Zebrafish Brain Development. Genes. 15(3):
- Zhang, J., Guo, S., Tao, R., Wang, F., Xie, Y., Wang, H., Ding, L., Shen, Y., Zhou, X., Feng, J., Shen, Q. (2023) Neuroprotective effect of plasmalogens on AlCl3-induced Alzheimer's disease zebrafish via acting on the regulatory network of ferroptosis, apoptosis and synaptic neurotransmission release with oxidative stress as the center. Neuroscience letters. 818:137560
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Zuccarini, G., D'Atri, I., Cottone, E., Mackie, K., Shainer, I., Gothilf, Y., Provero, P., Bovolin, P., Merlo, G.R. (2019) Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos. International Journal of Molecular Sciences. 21(1):
- Jiang, P., Hou, Y., Fu, W., Tao, X., Luo, J., Lu, H., Xu, Y., Han, B., Zhang, J. (2018) Characterization of lncRNAs involved in cold acclimation of zebrafish ZF4 cells. PLoS One. 13:e0195468
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wang, X., Du, X., Li, H., Zhang, S. (2016) Identification of the zinc finger protein ZRANB2 as a novel maternal LPS-binding protein that protects embryos of zebrafish against Gram-negative bacterial infections. The Journal of biological chemistry. 291(8):4019-34
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