Gene

myo6a

ID

ZDB-GENE-040819-2

Name

myosin VIa

Symbol

myo6a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in angioblast cell migration from lateral mesoderm to midline and artery morphogenesis. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Is expressed in dorsal aorta; neural tube; posterior cardinal vein; and somite. Orthologous to human MYO6 (myosin VI).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo6a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 22	Alliance	Deafness, autosomal dominant 22	606346
autosomal dominant nonsyndromic deafness 22	Alliance	Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy	606346
autosomal recessive nonsyndromic deafness 37	Alliance	Deafness, autosomal recessive 37	607821

Associated With myo6a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR001609	Myosin head, motor domain
Domain	IPR004009	Myosin, N-terminal, SH3-like
Domain	IPR032412	Myosin VI, cargo binding domain
Domain	IPR036114	Class VI myosin, motor domain
Domain	IPR049016	Myosin VI, lever arm
Homologous_superfamily	IPR008989	Myosin S1 fragment, N-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Class VI myosin, motor domain	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	Myosin head, motor domain	Myosin, N-terminal, SH3-like	Myosin S1 fragment, N-terminal	Myosin VI, cargo binding domain	Myosin VI, lever arm	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M2B757 InterPro	1278
UniProtKB:A0A8M9PBP4 InterPro	1150
UniProtKB:F1Q6Q6 InterPro	1253
UniProtKB:A0A8M9P2J2 InterPro	1153
UniProtKB:A0A8M3AL94 InterPro	1281
UniProtKB:A0A8M3AVX0 InterPro	1268
UniProtKB:A0A8M9PH95 InterPro	1288
UniProtKB:A0A8M3ASY2 InterPro	1256

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	myo6a-202 (1) Ensembl	Havana	5010 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	myo6a-203 (1) Ensembl	Havana	4988 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	myo6a-205 (1) Ensembl	Havana	542 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	myo6a-003 (1) Ensembl	Havana	536 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations