Gene

ndufv1

ID

ZDB-GENE-040808-73

Name

NADH:ubiquinone oxidoreductase core subunit V1

Symbol

ndufv1 Nomenclature History

Previous Names

wu:fc01f01
wu:fc12f12
zgc:86620

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have several functions, including 4 iron, 4 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and coenzyme binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to localize to mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in mitochondrial complex I deficiency. Is expressed in several structures, including alar plate midbrain region; immature eye; musculature system; optic tectum; and pronephric duct. Orthologous to human NDUFV1 (NADH:ubiquinone oxidoreductase core subunit V1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6892746 (1 image)
IMAGE:7157113 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ndufv1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nuclear type mitochondrial complex I deficiency 4	Alliance	Mitochondrial complex I deficiency, nuclear type 4	618225

Associated With ndufv1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001949	NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
Domain	IPR011538	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
Domain	IPR019575	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain
Family	IPR011537	NADH ubiquinone oxidoreductase, F subunit
Homologous_superfamily	IPR037207	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily
Homologous_superfamily	IPR037225	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily

Domain Details Per Protein

Protein	Length	NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily	NADH ubiquinone oxidoreductase, F subunit
UniProtKB:Q6AZA2 InterPro	492

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ndufv1-201 (1) Ensembl	Havana	1915 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ndufv1-003 (1) Ensembl	Havana	1310 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations