Gene
acat1
- ID
- ZDB-GENE-040808-68
- Name
- acetyl-CoA acetyltransferase 1
- Symbol
- acat1 Nomenclature History
- Previous Names
-
- fd16h07
- fd20g06
- wu:fd16h07
- wu:fd20g06
- zgc:86832
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Is expressed in liver. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157078 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| beta-ketothiolase deficiency | Alliance | Alpha-methylacetoacetic aciduria | 203750 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR020610 | Thiolase, active site |
| Active_site | IPR020615 | Thiolase, acyl-enzyme intermediate active site |
| Conserved_site | IPR020613 | Thiolase, conserved site |
| Domain | IPR020616 | Thiolase, N-terminal |
| Domain | IPR020617 | Thiolase, C-terminal |
| Family | IPR002155 | Thiolase |
| Homologous_superfamily | IPR016039 | Thiolase-like |
Domain Details Per Protein
| Protein | Length | Thiolase | Thiolase, active site | Thiolase, acyl-enzyme intermediate active site | Thiolase, conserved site | Thiolase, C-terminal | Thiolase-like | Thiolase, N-terminal |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6AZA0
|
420 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available